All Phenotypes Cul4b<tm1.1Pz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cul4b^tm1.1Pz
targeted mutation 1.1, Pengbo Zhou
MGI:5502166

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul4b^tm1.1Pz/Cul4b^tm1.1Pz	involves: 129 * C57BL/6J	MGI:5502169
cn2	Cul4b^tm1.1Pz/Y Tg(CAG-cre)13Miya/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:5502170
cn3	Cul4b^tm1.1Pz/Cul4b⁺ Tg(CAG-cre)13Miya/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:5502171
cn4	Cul4b^tm1.1Pz/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:5502172
cn5	Cul4b^tm1.1Pz/Cul4b⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:5502173
ot6	Cul4b^tm1.1Pz/Y	involves: 129 * C57BL/6J	MGI:5502168

Allelic Composition	Cul4b^tm1.1Pz/Cul4b^tm1.1Pz
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Pz mutation (0 available); any Cul4b mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:199210 )

• mice are healthy and indistinguishable from wild-type mice

Allelic Composition	Cul4b^tm1.1Pz/Y Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Pz mutation (0 available); any Cul4b mutation (37 available)
Tg(CAG-cre)13Miya mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199210 )

• despite being present at E8.5, no mice are identified beyond E9.5

embryo

increased embryonic tissue cell apoptosis ( J:199210 )

• in embryonic and extra-embryonic ectoderms

abnormal embryo development ( J:199210 )

• at E7.5, mice exhibit compact, indiscernible, structures, underdeveloped cavities and absent ectoplacental cones compared with wild-type mice

abnormal ectoderm development ( J:199210 )

• disorganized and reduced in size

embryonic growth arrest ( J:199210 )

decreased embryo size ( J:199210 )

• in 2 of 11 mice at E8.5

failure of primitive streak formation ( J:199210 )

absent ectoplacental cone ( J:199210 )

• at E7.5

growth/size/body

decreased embryo size ( J:199210 )

• in 2 of 11 mice at E8.5

cellular

increased embryonic tissue cell apoptosis ( J:199210 )

• in embryonic and extra-embryonic ectoderms

decreased cell proliferation ( J:199210 )

• in E7.5 embryos and the placental cone and trophectoderm-derived tissues

Allelic Composition	Cul4b^tm1.1Pz/Cul4b⁺ Tg(CAG-cre)13Miya/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Pz mutation (0 available); any Cul4b mutation (37 available)
Tg(CAG-cre)13Miya mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:199210 )

• no mice are identified beyond E13.5 when the allele is inherited maternally

• however, live-born mice are produced when the allele is inherited paternally

embryo

abnormal vitelline vasculature morphology ( J:199210 )

• underdeveloped branching vitelline vessels at E12.5 when the allele is inherited maternally

cardiovascular system

abnormal vitelline vasculature morphology ( J:199210 )

• underdeveloped branching vitelline vessels at E12.5 when the allele is inherited maternally

Allelic Composition	Cul4b^tm1.1Pz/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Pz mutation (0 available); any Cul4b mutation (37 available)
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:199210 )

• mice are healthy and show no abnormal development

Allelic Composition	Cul4b^tm1.1Pz/Cul4b⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:199210 )

N	• live mice are produced in Mendelian ratios

Allelic Composition	Cul4b^tm1.1Pz/Y
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul4b^tm1.1Pz mutation (0 available); any Cul4b mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:199210 )

• mice are healthy and indistinguishable from wild-type mice

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