Phenotypes associated with this allele

• Allele Symbol: Cul4b^tm1.1Pz
• Allele Name: targeted mutation 1.1, Pengbo Zhou
• Allele ID: MGI:5502166
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul4b^tm1.1Pz/Cul4b^tm1.1Pz	involves: 129 * C57BL/6J	MGI:5502169
cn2	Cul4b^tm1.1Pz/Y Tg(CAG-cre)13Miya/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:5502170
cn3	Cul4b^tm1.1Pz/Cul4b^+ Tg(CAG-cre)13Miya/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:5502171
cn4	Cul4b^tm1.1Pz/Y Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:5502172
cn5	Cul4b^tm1.1Pz/Cul4b^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:5502173
ot6	Cul4b^tm1.1Pz/Y	involves: 129 * C57BL/6J	MGI:5502168

Genotype
MGI:5502169

hm1

• Allelic Composition: Cul4b^tm1.1Pz/Cul4b^tm1.1Pz
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:199210 )

♀ • mice are healthy and indistinguishable from wild-type mice

Genotype
MGI:5502170

cn2

• Allelic Composition: Cul4b^tm1.1Pz/Y; Tg(CAG-cre)13Miya/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199210 )

♂ • despite being present at E8.5, no mice are identified beyond E9.5

embryo

increased embryonic tissue cell apoptosis ( J:199210 )

♂ • in embryonic and extra-embryonic ectoderms

abnormal embryo development ( J:199210 )

♂ • at E7.5, mice exhibit compact, indiscernible, structures, underdeveloped cavities and absent ectoplacental cones compared with wild-type mice

abnormal ectoderm development ( J:199210 )

♂ • disorganized and reduced in size

embryonic growth arrest ( J:199210 )

♂

decreased embryo size ( J:199210 )

♂ • in 2 of 11 mice at E8.5

failure of primitive streak formation ( J:199210 )

♂

absent ectoplacental cone ( J:199210 )

♂ • at E7.5

growth/size/body

decreased embryo size ( J:199210 )

♂ • in 2 of 11 mice at E8.5

cellular

increased embryonic tissue cell apoptosis ( J:199210 )

♂ • in embryonic and extra-embryonic ectoderms

decreased cell proliferation ( J:199210 )

♂ • in E7.5 embryos and the placental cone and trophectoderm-derived tissues

Genotype
MGI:5502171

cn3

• Allelic Composition: Cul4b^tm1.1Pz/Cul4b⁺; Tg(CAG-cre)13Miya/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:199210 )

♀ • no mice are identified beyond E13.5 when the allele is inherited maternally

♀ • however, live-born mice are produced when the allele is inherited paternally

embryo

abnormal vitelline vasculature morphology ( J:199210 )

♀ • underdeveloped branching vitelline vessels at E12.5 when the allele is inherited maternally

cardiovascular system

abnormal vitelline vasculature morphology ( J:199210 )

♀ • underdeveloped branching vitelline vessels at E12.5 when the allele is inherited maternally

Genotype
MGI:5502172

cn4

• Allelic Composition: Cul4b^tm1.1Pz/Y; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

normal phenotype

no abnormal phenotype detected ( J:199210 )

♂ • mice are healthy and show no abnormal development

Genotype
MGI:5502173

cn5

• Allelic Composition: Cul4b^tm1.1Pz/Cul4b⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

mortality/aging

mortality/aging ( J:199210 )

♀N • live mice are produced in Mendelian ratios

Genotype
MGI:5502168

ot6

• Allelic Composition: Cul4b^tm1.1Pz/Y
• Genetic Background: involves: 129 * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:199210 )

♂ • mice are healthy and indistinguishable from wild-type mice