Analysis Tools
mortality/aging
| N |
• born in expected numbers
|
growth/size/body
| N |
• mice are developmentally normal at birth
• body weights are normal and mice remain healthy past 1 year of age
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immune system
| N |
• primary lymphoid follicles form normally
• response to T cell independent antigens is normal
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|
• considerably fewer follicular helper T cells both before and after immunization
|
|
• primary lymphoid follicles form normally but no germinal centers are found in un-immunized mice
|
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• fewer germinal centers found after immunization than in controls
• B cells almost absent both before and 10 days after immunization
|
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• germinal centers also lost in Peyer's patches
|
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• early low affinity response to T cell dependent antigens is normal
• later higher affinity responses are reduced
|
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• lower proliferation of germinal center B cells
• cell arrest in the G1 stage
• higher apoptosis rate
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hematopoietic system
|
• considerably fewer follicular helper T cells both before and after immunization
|
|
• primary lymphoid follicles form normally but no germinal centers are found in un-immunized mice
|
|
• fewer germinal centers found after immunization than in controls
• B cells almost absent both before and 10 days after immunization
|
|
• lower proliferation of germinal center B cells
• cell arrest in the G1 stage
• higher apoptosis rate
|
