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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ackr3tm1Yzo
targeted mutation 1, Yong-Rui Zou
MGI:5502184
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ackr3tm1Yzo/Ackr3tm1Yzo Not Specified MGI:5502186


Genotype
MGI:5502186
hm1
Allelic
Composition		 Ackr3tm1Yzo/Ackr3tm1Yzo
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ackr3tm1Yzo mutation (0 available); any Ackr3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal blood vessel morphology ( J:195048 )
• some small vessel branches fail to associate with nerves unlike in wild-type mice
• however, mice exhibit normal arterial differentiation, smooth muscle coverage and vascular remodeling in the limb skin with most remodeled vessels align with nerves

nervous system
nervous system phenotype ( J:195048 )
N
• mice exhibit normal innervation accompanied by migrating Schwann cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory