hearing/vestibular/ear
N |
• mice exhibit normal vestibular function, Reissner's membrane, stria vascularis and strial ganglion neurons, middle ear morphology and inner hair cells
|
• at 2 weeks
|
• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
|
• cellular degeneration at 9 weeks
|
• at 2 weeks in only the highest frequency
• at 4 and 9 weeks of age
• however, no further decline is observed between 9 week and 1 year
|
vision/eye
• highly variable eye pathology ranging from microphthalmia to normal eyes to bulging eyes
• however, retinal pigment epithelium appears normal at P0
|
exophthalmos
(
J:226897
)
• in some mice
|
• in some mice
|
• eyes are open at birth
|
• rosetting
|
• mice fail to respond in an optokinetic drum visual-function assay
|
behavior/neurological
• reduced Preyers response to a click-box auditory stimulus
|
nervous system
• at 2 weeks
|
• at 4 weeks with increasing severity from apex to base
• further degeneration at 9 weeks
|