Phenotypes associated with this allele

• Allele Symbol: Ajap1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5502312
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ajap1^tm1b(EUCOMM)Hmgu/Ajap1^tm1b(EUCOMM)Hmgu	B6N(Cg)-Ajap1^tm1b(EUCOMM)Hmgu/J	MGI:5763831
hm2	Ajap1^tm1b(EUCOMM)Hmgu/Ajap1^tm1b(EUCOMM)Hmgu	involves: BALB/cJ * C57BL/6N	MGI:6364113

Genotype
MGI:5763831

hm1

• Allelic Composition: Ajap1^{tm1b(EUCOMM)Hmgu}/Ajap1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: B6N(Cg)-Ajap1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0583_2_B09

Data Sources

IMPC Data for Ajap1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - JAX

decreased thigmotaxis ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating potassium level ( J:211773 )

♂

IMPC - JAX

increased circulating sodium level ( J:211773 )

♀

IMPC - JAX

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - JAX

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - JAX

increased circulating total protein level ( J:211773 )

♀

IMPC - JAX

increased circulating chloride level ( J:211773 )

♀

IMPC - JAX

skeleton

abnormal bone structure ( J:211773 )

♀

IMPC - JAX

decreased bone mineral content ( J:211773 )

♀

IMPC - JAX

Genotype
MGI:6364113

hm2

• Allelic Composition: Ajap1^{tm1b(EUCOMM)Hmgu}/Ajap1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: involves: BALB/cJ * C57BL/6N

nervous system

nervous system phenotype ( J:276486 )

N • normal response to baclofen-induced reduction of evoked EPSC amplitude