Phenotypes associated with this allele

• Allele Symbol: Nox4^tm1Kkr
• Allele Name: targeted mutation 1, Karl-Heinz Krause
• Allele ID: MGI:5502326
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nox4^tm1Kkr/Nox4^tm1Kkr	B6.129-Nox4^tm1Kkr	MGI:5502339

Genotype
MGI:5502339

hm1

• Allelic Composition: Nox4^tm1Kkr/Nox4^tm1Kkr
• Genetic Background: B6.129-Nox4^tm1Kkr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:199354 )

• alveolar epithelial cell of bleomycin-treated mice or stimulated by TGFB1

oxidative stress ( J:199354 )

• reduced in alveolar epithelial cells treated with TGFB1

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:199354 )

• mice exhibit decreased bleomycin-induced weight loss, lung fibrosis, accumulation of myofibroblasts and alveolar epithelial cell death compared with wild-type mice

• however, bleomycin-induced inflammation is normal

growth/size/body

decreased susceptibility to weight loss ( J:199354 )

• in bleomycin-treated mice

respiratory system

abnormal lung morphology ( J:199354 )

• mice exhibit decreased bleomycin-induced lung fibrosis compared with wild-type mice