About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nabp2tm1.1Kkha
targeted mutation 1.1, Kum Kum Khanna
MGI:5502334
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:5502352
cn2
 		Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6 * C57BL/6NTac MGI:5502351


Genotype
MGI:5502352
cn1
Allelic
Composition		 Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Nabp2tm1.1Kkha mutation (1 available); any Nabp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:195140 )
N
• mice exhibit normal class switch recombination




Genotype
MGI:5502351
cn2
Allelic
Composition		 Nabp2tm1.1Kkha/Nabp2tm1.1Kkha
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Nabp2tm1.1Kkha mutation (1 available); any Nabp2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Testicular degeneration in Nabp2tm1.1Kkha/Nabp2tm1.1Kkha Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ mice

mortality/aging

reproductive system
reproductive system phenotype ( J:195140 )
N
• tamoxifen-treated female mice exhibit normal fertility
abnormal male germ cell morphology ( J:195140 )
• premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
oligozoospermia ( J:195140 )
• due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
• decreased elongated spermatids
abnormal male germ cell apoptosis ( J:195140 )
• in tamoxifen-treated mice
small testis ( J:195140 )
• in tamoxifen-treated mice
decreased testis weight ( J:195140 )
• in tamoxifen-treated mice
testis degeneration ( J:195140 )
• bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice
decreased litter size ( J:195140 )
• from tamoxifen-treated mice with longer intervals between litters
reduced male fertility ( J:195140 )
• in tamoxifen-treated mice

neoplasm
increased tumor incidence ( J:195140 )
• splenic and metastatic B lymphomas, T cell lymphoma in thymus, hepatocellular carcinoma and B or T lymphoblastic leukemia in 11 of 35 of tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice
increased hepatocellular carcinoma incidence ( J:195140 )
• in some tamoxifen-treated mice
increased leukemia incidence ( J:195140 )
• B or T lymphoblastic leukemia in some tamoxifen-treated mice
increased B cell derived lymphoma incidence ( J:195140 )
• splenic and metastatic B lymphomas in some tamoxifen-treated mice

cellular
abnormal male germ cell morphology ( J:195140 )
• premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
oligozoospermia ( J:195140 )
• due to apoptosis and premature sloughing from the supporting Sertoli cells in tamoxifen-treated mice
• decreased elongated spermatids
increased cellular sensitivity to ionizing radiation ( J:195140 )
• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies
• however, blood counts are normal in irradiated tamoxifen-treated mice
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
abnormal male germ cell apoptosis ( J:195140 )
• in tamoxifen-treated mice
chromosomal instability ( J:195140 )
• in tamoxifen-treated mice

growth/size/body
decreased body length ( J:195140 )
• at E14.5 and E18.5

digestive/alimentary system
abnormal small intestine morphology ( J:195140 )
• tamoxifen-treated mice exposed to ionizing radiation exhibit distended crypt lumina lined by attenuated enterocytes, desquamated necrotic cellular debris and a small increase of cells near deep crypts with apoptotic bodies

immune system
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice

endocrine/exocrine glands
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice
small testis ( J:195140 )
• in tamoxifen-treated mice
decreased testis weight ( J:195140 )
• in tamoxifen-treated mice
testis degeneration ( J:195140 )
• bilateral degeneration; tubules showed degenerate, sometimes vacuolated, or necrotic spermatogenic cells, the latter with pyknotic nuclei and hypereosinophilic cytoplasm, or apoptotic body formation in tamoxifen-treated mice

hematopoietic system
hematopoietic system phenotype ( J:195140 )
N
• blood counts are normal in irradiated tamoxifen-treated mice
increased thymocyte apoptosis ( J:195140 )
• in irradiated tamoxifen-treated mice
increased T cell derived lymphoma incidence ( J:195140 )
• in thymus of some tamoxifen-treated mice

homeostasis/metabolism

liver/biliary system
increased hepatocellular carcinoma incidence ( J:195140 )
• in some tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory