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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(LRRK2*G2019S)2AMjff
transgene insertion 2A, The Michael J Fox Foundation
MGI:5502368
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(LRRK2*G2019S)2AMjff/0 C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J MGI:6798088


Genotype
MGI:6798088
tg1
Allelic
Composition		 Tg(LRRK2*G2019S)2AMjff/0
Genetic
Background		 C57BL/6J-Tg(LRRK2*G2019S)2AMjff/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LRRK2*G2019S)2AMjff mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal brain interneuron morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is more severe than in Lrrk2tm4.1Arte homozygotes
• fewer and shorter cilia on striatal astrocytes
• however, cilia on surrounding neurons are normal
abnormal dorsal striatum morphology ( J:312767 )
• loss of primary cilia on choline acetyltransferase interneurons of the dorsal striatum that is more severe than in Lrrk2tm4.1Arte homozygotes
• fewer and shorter cilia on striatal astrocytes
• however, cilia on surrounding neurons are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory