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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdkn2atm1.1Gsu
targeted mutation 1.1, Gloria H Su
MGI:5502377
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5502380
cn2
 		Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu
Tg(Pdx1-cre)6Tuv/0 		involves: 129S4/SvJaeSor * C57BL/6J * FVB/N MGI:5502379


Genotype
MGI:5502380
cn1
Allelic
Composition		 Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Gsu mutation (1 available); any Cdkn2a mutation (67 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:198619 )
• median survival 25.5 weeks

neoplasm
increased pancreas tumor incidence ( J:198619 )
• starting between 6 and 24 weeks with metastasis
increased pancreas adenoma incidence ( J:198619 )
• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas
increased adenocarcinoma incidence ( J:198619 )
• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas

growth/size/body
weight loss ( J:198619 )
• starting between 6 and 24 weeks
distended abdomen ( J:198619 )
• increased girth starting between 6 and 24 weeks

liver/biliary system
jaundice ( J:198619 )
• starting between 6 and 24 weeks

homeostasis/metabolism
ascites ( J:198619 )
• starting between 6 and 24 weeks

endocrine/exocrine glands
increased pancreas tumor incidence ( J:198619 )
• starting between 6 and 24 weeks with metastasis
increased pancreas adenoma incidence ( J:198619 )
• adenocarcinomas in 9 of 9 invasive carcinomas in the pancreas




Genotype
MGI:5502379
cn2
Allelic
Composition		 Cdkn2atm1.1Gsu/Cdkn2atm1.1Gsu
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1.1Gsu mutation (1 available); any Cdkn2a mutation (67 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:198619 )
N
• mice do not develop pancreatic neoplasms




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory