Phenotypes associated with this allele

• Allele Symbol: Abhd5^tm1Rze
• Allele Name: targeted mutation 1, Rudolf Zechner
• Allele ID: MGI:5502402
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abhd5^tm1Rze/Abhd5^tm1Rze Tg(Ckmm-cre)5Khn/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:5502413

Genotype
MGI:5502413

cn1

• Allelic Composition: Abhd5^tm1Rze/Abhd5^tm1Rze; Tg(Ckmm-cre)5Khn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased heart weight ( J:197835 )

• 1.6-fold

mortality/aging

premature death ( J:197835 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:197835 )

N • mitochondrial fatty acid oxidation and triglyceride hydrolutic activities in skeletal muscle are normal

N • mice exhibit normal insulin sensitivity

decreased oxygen consumption ( J:197835 )

• in cardiac muscle

increased respiratory quotient ( J:197835 )

• during the light and dark phase

abnormal glucose homeostasis ( J:197835 )

• glucose clearance is enhanced

decreased circulating glucose level ( J:197835 )

• in fasted mice

• in re-fed mice

decreased circulating insulin level ( J:197835 )

• in re-fed mice

improved glucose tolerance ( J:197835 )

abnormal lipid homeostasis ( J:197835 )

• exercised mice fail to exhibit a decrease in the skeletal muscle indicating a defect in skeletal muscle triglyceride catabolism compared with control mice

increased cardiac muscle triglyceride level ( J:197835 )

• 43-fold in the cardiac muscle of non-fasted mice

• 15-fold in the cardiac muscle of fasted mice

decreased circulating free fatty acids level ( J:197835 )

• in non-exercised and exercised mice

decreased circulating triglyceride level ( J:197835 )

• in exercised mice

decreased liver triglyceride level ( J:197835 )

• moderate in fasted mice

increased skeletal muscle triglyceride level ( J:197835 )

• marked accumulation of triglycerides in skeletal muscle

• exercised mice fail to exhibit a decrease in skeletal muscle compared with control mice

decreased lipoprotein lipase activity ( J:197835 )

• mild increase in LPA acyltransferase activity

impaired lipolysis ( J:197835 )

• in cardiac muscle

• however, in vitro triglyceride hydrolytic activity in skeletal muscle is normal

cardiovascular system

increased cardiac muscle triglyceride level ( J:197835 )

• 43-fold in the cardiac muscle of non-fasted mice

• 15-fold in the cardiac muscle of fasted mice

myocardium steatosis ( J:197835 )

increased heart weight ( J:197835 )

• 1.6-fold

abnormal heart left ventricle morphology ( J:197835 )

• septal and posterial wall thickening

increased heart left ventricle weight ( J:197835 )

increased cardiac muscle cell glucose uptake ( J:197835 )

• increased 6.7-fold

• however, glucose uptake in skeletal muscle, liver and adipose tissue is normal

decreased heart left ventricle muscle contractility ( J:197835 )

• left ventricle

muscle

increased cardiac muscle triglyceride level ( J:197835 )

• 43-fold in the cardiac muscle of non-fasted mice

• 15-fold in the cardiac muscle of fasted mice

myocardium steatosis ( J:197835 )

increased cardiac muscle cell glucose uptake ( J:197835 )

• increased 6.7-fold

• however, glucose uptake in skeletal muscle, liver and adipose tissue is normal

decreased heart left ventricle muscle contractility ( J:197835 )

• left ventricle

increased skeletal muscle triglyceride level ( J:197835 )

• marked accumulation of triglycerides in skeletal muscle

• exercised mice fail to exhibit a decrease in skeletal muscle compared with control mice

liver/biliary system

decreased liver triglyceride level ( J:197835 )

• moderate in fasted mice

cellular

increased cardiac muscle cell glucose uptake ( J:197835 )

• increased 6.7-fold

• however, glucose uptake in skeletal muscle, liver and adipose tissue is normal