Phenotypes associated with this allele

• Allele Symbol: Tg(Cela1-tTA)#Eps
• Allele Name: transgene insertion, Eric P Sandgren
• Allele ID: MGI:5502418
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kras^tm1Bbd/Kras^+ Trp53^tm1Brd/Trp53^+ Tg(Cela1-tTA)#Eps/? Tg(tetO-cre)3Jig/?	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N	MGI:5502432
cn2	Kras^tm1Bbd/Kras^tm1Bbd Tg(Cela1-tTA)#Eps/? Tg(tetO-cre)3Jig/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5502430

Genotype
MGI:5502432

cn1

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Trp53^tm1Brd/Trp53⁺; Tg(Cela1-tTA)#Eps/?; Tg(tetO-cre)3Jig/?
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:119988 )

• 50% mortality by 6 months of age

• 100% mortality by 1 year of age

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions

increased metastatic potential ( J:119988 )

• metastases develop affecting liver, diaphragm, lungs, lymph nodes, and spleen

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:119988

Genotype
MGI:5502430

cn2

• Allelic Composition: Kras^tm1Bbd/Kras^tm1Bbd; Tg(Cela1-tTA)#Eps/?; Tg(tetO-cre)3Jig/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• focal morphological lesions develop in acinar and centroacinar cells at 1-3 months

• acinar to ductal metaplasias develop

• some mice develop ductal adenocarcinomas by 12 months

• properties are similar to those in human patients

• sometimes areas of non malignant hyperplasia develop

increased tumor latency ( J:119988 )

• latency is increased if gene expression is delayed by maintaining exposure to doxycycline until 10 days of age

• if doxycycline exposure continues to 2 months of age, no pancreatic abnormalities develop

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:119988 )

• focal morphological lesions develop in acinar and centroacinar cells at 1-3 months

• acinar to ductal metaplasias develop

• some mice develop ductal adenocarcinomas by 12 months

• properties are similar to those in human patients

• sometimes areas of non malignant hyperplasia develop

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:119988