Phenotypes associated with this allele

• Allele Symbol: Gbx1^tm1.1Stwt
• Allele Name: targeted mutation 1.1, Samuel T Waters
• Allele ID: MGI:5502431
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt	involves: C57BL/6 * FVB/N	MGI:5502440

Genotype
MGI:5502440

hm1

• Allelic Composition: Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Locomotive defect affecting hindlimb gait in Gbx1^tm1.1Stwt/Gbx1^tm1.1Stwt mice

nervous system

nervous system phenotype ( J:197199 )

N • mice exhibit normal generation of the neuronal population that relay motor output signals to the periphery

decreased motor neuron number ( J:197199 )

• in peripherin+, Isl1+ and Isl1+/peripherin+ ventral motor neurons

abnormal proprioceptive neuron morphology ( J:197199 )

• abnormal projection of proprioceptive sensory axons

• at E17.5, projections of proprioceptive afferents into the ventral termination zone (group Ia afferents) is nearly absent compared with control mice

• however, the population of proprioceptive sensory neuron cell bodies in the dorsal root ganglion is normal

behavior/neurological

abnormal locomotor behavior ( J:197199 )

• severe defect by P15 affecting hindlimb locomotion

abnormal gait ( J:197199 )

• hindlimb gait described as a prolonged step cycle period with overall increased amplitude of the locomotive rhythm as early as P15 and persistent until death