About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2ak3tm1.2Drc
targeted mutation 1.2, Douglas R Cavener
MGI:5502572
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Eif2ak3tm1.2Drc/Eif2ak3tm1.2Drc
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-MYC,-GFP*)#Rugg/0
Tg(Pbsn-cre)4Prb/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2 MGI:6198768


Genotype
MGI:6198768
cn1
Allelic
Composition		 Eif2ak3tm1.2Drc/Eif2ak3tm1.2Drc
Ptentm1Hwu/Ptentm1Hwu
Tg(CAG-MYC,-GFP*)#Rugg/0
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak3tm1.2Drc mutation (1 available); any Eif2ak3 mutation (53 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(CAG-MYC,-GFP*)#Rugg mutation (0 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

neoplasm
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice

reproductive system
decreased prostate gland tumor incidence ( J:261540 )
• mice show reduced prostate growth, with a decrease prostate cancer progression and cell proliferation compared to Ptentm1Hwu/Ptentm1Hwu Tg(Pbsn-cre)4Prb/0 Tg(CAG-MYC,-GFP)#Rugg/0 mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory