Phenotypes associated with this allele

• Allele Symbol: Hsd11b1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:5502586
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex	B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc	MGI:5502603

Genotype
MGI:5502603

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Hsd11b1^tm1Lex/Hsd11b1^tm1Lex
• Genetic Background: B6.129-Hsd11b1^tm1Lex Apoe^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased aortic root atherosclerosis susceptibility in Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex mice

immune system

immune system phenotype ( J:199430 )

N • mice fed a high fat diet and subjected to intraperitoneal thioglycollate challenge exhibit normal inflammatory cell migration

abnormal macrophage derived foam cell morphology ( J:199430 )

• foam cells from mice fed a high fat diet exhibit reduced cholesterol content compared with control cells

decreased macrophage cell number ( J:199430 )

• in atherosclerotic lesions of mice fed a high fat diet

abnormal cytokine secretion ( J:199430 )

• peritoneal foam cells treated with oxidized LDL exhibit reduced secretion of G-CSF, KC, MCP-1 and TNFalpha compared with control cells

decreased tumor necrosis factor secretion ( J:199430 )

• in peritoneal foam cells treated with oxidized LDL

homeostasis/metabolism

hyperlipidemia ( J:199430 )

• in mice fed a high fat diet as in Apoe^tm1Unc homozygotes

decreased cholesterol level ( J:199430 )

• decreased total, 7-ketocholesterol and 7beta-hydroxycholesterol levels in the aorta of mice fed a high fat diet compared with similarly treated Apoe^tm1Unc homozygotes

• foam cells from mice fed a high fat diet exhibit reduced cholesterol content compared with control cells

cardiovascular system

cardiovascular system phenotype ( J:199430 )

N • mice fed a high fat diet exhibit normal blood pressure

decreased susceptibility to atherosclerosis ( J:199430 )

• decreased total, 7-ketocholesterol and 7beta-hydroxycholesterol levels in the aorta of mice fed a high fat diet compared with similarly treated Apoe^tm1Unc homozygotes

• foam cells from mice fed a high fat diet exhibit reduced cholesterol content compared with control cells

behavior/neurological

behavior/neurological phenotype ( J:199430 )

N • mice fed a high fat diet exhibit normal behavior

growth/size/body

growth/size/body region phenotype ( J:199430 )

N • mice fed a high fat diet exhibit normal weight gain

hematopoietic system

abnormal macrophage derived foam cell morphology ( J:199430 )

• foam cells from mice fed a high fat diet exhibit reduced cholesterol content compared with control cells

decreased macrophage cell number ( J:199430 )

• in atherosclerotic lesions of mice fed a high fat diet

abnormal bone marrow cell physiology ( J:199430 )

• bone marrow-derived stem cells transferred into Apoe^tm1Unc recipient fed a high fat diet results in decreased atherosclerosis in whole thoracic aorta and descending aorta

cellular

abnormal macrophage derived foam cell morphology ( J:199430 )

• foam cells from mice fed a high fat diet exhibit reduced cholesterol content compared with control cells