Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-EGFP/AC3I)#Mean transgene insertion, Mark Anderson MGI:5502606 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• that is slightly less than in Ryr2tm2.1Wex homozygotes
• incidence of tachycardia in isoproterenol-treated mice is the same as in Ryr2tm2.1Wex homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• STZ-treated mice subjected to myocardial infarction exhibit resistance to increased mortality compared with similarly treated wild-type mice
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• STZ-treated mice subjected to myocardial infarction (MI) exhibit improved intrinsic sinus node function compared with similarly treated wild-type mice
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• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice
• however, STZ mice subjected to MI exhibit normal left ventricle contractile function and volume
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• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice
• however, STZ mice subjected to MI exhibit normal left ventricle contractile function and volume
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• in the sinoatrial node of STZ-treated mice subjected to myocardial infarction
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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