All Phenotypes Ank1<ity16> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ank1^ity16
immunity to Typhimurium locus 16
MGI:5502651

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ank1^ity16/Ank1^ity16	involves: 129S1/Sv * 129X1/SvJ * DBA/2J	MGI:5502658
ht2	Ank1^ity16/Ank1⁺	involves: 129S1/Sv * 129X1/SvJ * DBA/2J	MGI:5502659

Allelic Composition	Ank1^ity16/Ank1^ity16
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^ity16 mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Extensive extramedullary erythropoiesis in the spleen and liver, severe lymphoid depletion, and increase in iron pigment deposition the liver and kidney of Ank1^ity16/Ank1^ity16 mice

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• severe in uninfected mice and worsened in mice infected with Salmonella Typhimurium

hematopoietic system

enlarged spleen ( J:199427 )

hemolytic anemia ( J:199427 )

• severe in uninfected mice and worsened in mice infected with Salmonella Typhimurium

abnormal erythrocyte morphology ( J:199427 )

abnormal erythropoiesis ( J:199427 )

• extensive extramedullary erythropoiesis in the spleen and liver

decreased erythrocyte cell number ( J:199427 )

• in uninfected mice and worsened in mice infected with Salmonella Typhimurium

decreased hematocrit ( J:199427 )

• severe in uninfected mice and worsened in mice infected with Salmonella Typhimurium

decreased hemoglobin content ( J:199427 )

• in mice infected with Salmonella Typhimurium

anisocytosis ( J:199427 )

increased leukocyte cell number ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased neutrophil cell number ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased lymphocyte cell number ( J:199427 )

• in uninfected mice and in mice infected with Salmonella Typhimurium

reticulocytosis ( J:199427 )

• in uninfected mice and in mice infected with Salmonella Typhimurium

decreased spleen iron level ( J:199427 )

homeostasis/metabolism

decreased spleen iron level ( J:199427 )

increased blood urea nitrogen level ( J:199427 )

• in uninfected mice and mice infected with Salmonella Typhimurium

increased circulating bilirubin level ( J:199427 )

increased circulating alanine transaminase level ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased circulating aspartate transaminase level ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased kidney iron level ( J:199427 )

• in the cytoplasm of epithelium of the renal tubules of uninfected mice and in mice infected with Salmonella Typhimurium

increased liver iron level ( J:199427 )

• predominantly in hepatocytes of uninfected mice and in mice infected with Salmonella Typhimurium

immune system

enlarged spleen ( J:199427 )

increased leukocyte cell number ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased neutrophil cell number ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased lymphocyte cell number ( J:199427 )

• in uninfected mice and in mice infected with Salmonella Typhimurium

decreased spleen iron level ( J:199427 )

glomerulonephritis ( J:199427 )

• membranoproliferative glomerulonephritis in mice infected with Salmonella typhimurium

increased susceptibility to bacterial infection ( J:199427 )

• mice infected with Salmonella Typhimurium exhibit increased bacterial proliferation in the liver (30 to 100 times higher load) and kidneys (10 times higher load) and increased lethality compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• severe in uninfected mice and worsened in mice infected with Salmonella Typhimurium

renal/urinary system

increased kidney weight ( J:199427 )

increased kidney iron level ( J:199427 )

• in the cytoplasm of epithelium of the renal tubules of uninfected mice and in mice infected with Salmonella Typhimurium

glomerulonephritis ( J:199427 )

• membranoproliferative glomerulonephritis in mice infected with Salmonella typhimurium

abnormal glomerular mesangium morphology ( J:199427 )

• enlarged in mice infected with Salmonella Typhimurium

liver/biliary system

increased liver iron level ( J:199427 )

• predominantly in hepatocytes of uninfected mice and in mice infected with Salmonella Typhimurium

liver abscess ( J:199427 )

• in mice infected with Salmonella Typhimurium

jaundice ( J:199427 )

cardiovascular system

increased heart weight ( J:199427 )

growth/size/body

increased heart weight ( J:199427 )

decreased body weight ( J:199427 )

increased kidney weight ( J:199427 )

enlarged spleen ( J:199427 )

Allelic Composition	Ank1^ity16/Ank1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ank1^ity16 mutation (0 available); any Ank1 mutation (106 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Progression of lesions in kidney and liver after Salmonella infection of Ank1^ity16/Ank⁺ and Ank1^ity16/Ank1^ity16 mice

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• intermediate in mice infected with Salmonella Typhimurium

hematopoietic system

extramedullary hematopoiesis ( J:199427 )

• in the liver

increased erythrocyte cell number ( J:199427 )

• small in uninfected mice and mice infected with Salmonella Typhimurium

homeostasis/metabolism

increased kidney iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

increased liver iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

immune system

increased susceptibility to bacterial infection ( J:199427 )

• mice infected with Salmonella Typhimurium exhibit increased bacterial load in the spleen, liver and kidney and increased mortality compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:199427 )

• intermediate in mice infected with Salmonella Typhimurium

liver/biliary system

increased liver iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

renal/urinary system

increased kidney iron level ( J:199427 )

• in mice infected with Salmonella Typhimurium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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