Phenotypes associated with this allele

• Allele Symbol: Polg^tm1Jiha
• Allele Name: targeted mutation 1, Jun-Ichi Hayashi
• Allele ID: MGI:5502688
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polg^tm1Jiha/Polg^tm1Jiha	involves: C57BL/6JJcl	MGI:5502691
ht2	Polg^tm1Jiha/Polg^+	involves: C57BL/6JJcl	MGI:5502692

Genotype
MGI:5502691

hm1

• Allelic Composition: Polg^tm1Jiha/Polg^tm1Jiha
• Genetic Background: involves: C57BL/6JJcl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Kyphosis in Polg^tm1Jiha/Polg^tm1Jiha and Del(MTmt-Tk-mt-Nd5)1Jiha mice

mortality/aging

premature death ( J:199416 )

• median survival is 10 months compared to 26 months for control mice

homeostasis/metabolism

decreased circulating glucose level ( J:199416 )

increased circulating lactate level ( J:199416 )

• increased circulating lactate levels

skeleton

kyphosis ( J:199416 )

cellular

abnormal oxidative phosphorylation ( J:199416 )

• reduced mitochondrial cytochrome c oxidase activity

integument

integument phenotype ( J:199416 )

N • unlike other mice with mitochondria mutator mutations, mice do not exhibit alopecia

Genotype
MGI:5502692

ht2

• Allelic Composition: Polg^tm1Jiha/Polg⁺
• Genetic Background: involves: C57BL/6JJcl

Mitochondrial respiration defects in Polg^tm1Jiha/Polg⁺, Polg^tm1Jiha/Polg^tm1Jiha, and Del(MTmt-Tk-mt-Nd5)1Jiha mice

mortality/aging

mortality/aging ( J:199416 )

N • mice exhibit normal survival

neoplasm

increased B cell derived lymphoma incidence ( J:199416 )

• in the spleen, liver, lung, and/or lymph nodes

increased incidence of induced tumors ( J:199416 )

• 15 of 29 mice exhibit tumor-like abnormalities in the spleen, liver and/or lymph nodes compared with 2 of 12 wild-type mice

cellular

abnormal oxidative phosphorylation ( J:199416 )

• mildly reduced mitochondrial cytochrome c oxidase activity

oxidative stress ( J:199416 )

• increased mitochondrial reactive oxygen species in the bone marrow of mice that develop B cell lymphomas

hematopoietic system

abnormal bone marrow cell physiology ( J:199416 )

• increased mitochondrial reactive oxygen species in the bone marrow of mice that develop B cell lymphomas