All Phenotypes Ighg1<tm1.1Pyu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ighg1^tm1.1Pyu
targeted mutation 1.1, Philipp Yu
MGI:5502698

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu	B6.C(Cg)-Ighg1^tm1.1Pyu	MGI:5502733
ht2	Ighg1^tm1.1Pyu/Ighg1⁺	B6.C(Cg)-Ighg1^tm1.1Pyu	MGI:5502732
cx3	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502734
cx4	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502736

Allelic Composition	Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu
Genetic Background	B6.C(Cg)-Ighg1^tm1.1Pyu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice sensitized with TNP-ovalbumin

immune system

immune system phenotype ( J:198154 )

N	• unchallenged mice exhibit normal production of IgG1 • challenged mice exhibit normal production of IgM

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 42-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• absent in unchallenged mice and mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2b level ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, unchallenged mice exhibit normal production of IgG2b

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice sensitized with TNP-ovalbumin

hematopoietic system

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 42-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• absent in unchallenged mice and mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2b level ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, unchallenged mice exhibit normal production of IgG2b

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Ighg1^tm1.1Pyu/Ighg1⁺
Genetic Background	B6.C(Cg)-Ighg1^tm1.1Pyu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:198154 )

N	• unchallenged mice exhibit normal production of IgG1 and IgG2b • challenged mice exhibit normal production of IgM

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

hematopoietic system

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24