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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhebtm1.1Otsu
targeted mutation 1.1, Kinya Otsu
MGI:5502740
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhebtm1.1Otsu/Rhebtm1.1Otsu involves: 129 * C57BL/6J MGI:5502746
cn2
 		Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0 		involves: 129 * C57BL/6J * FVB/N MGI:5502747
cn3
 		Eif4ebp1tm1Nso/Eif4ebp1tm1Nso
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0 		involves: 129 * C57BL/6J * FVB/N MGI:5502748
cn4
 		Atg5tm1Myok/Atg5tm1Myok
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0 		involves: 129S/SvEv * C57BL/6J * FVB/N MGI:5502749


Genotype
MGI:5502746
hm1
Allelic
Composition		 Rhebtm1.1Otsu/Rhebtm1.1Otsu
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebtm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:197831 )
• mice appeared normal




Genotype
MGI:5502747
cn2
Allelic
Composition		 Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhebtm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Sarcomere maturation is attenuated in Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds/0 hearts

mortality/aging
postnatal lethality, complete penetrance ( J:197831 )
• mice die between P8 and P10

cardiovascular system
abnormal heart left ventricle morphology ( J:197831 )
• reduced diastolic left ventricle posterior wall thickness
• larger end-diastolic and systolic dimensions
decreased cardiac muscle contractility ( J:197831 )
• reduced fractional shortening at P8
• however, cardiac function is normal until P5
cardiomyopathy ( J:197831 )
• without the involvement of autophagy

muscle
decreased cardiac muscle contractility ( J:197831 )
• reduced fractional shortening at P8
• however, cardiac function is normal until P5
cardiomyopathy ( J:197831 )
• without the involvement of autophagy
abnormal sarcomere morphology ( J:197831 )
• sarcomere maturation is attenuated




Genotype
MGI:5502748
cn3
Allelic
Composition		 Eif4ebp1tm1Nso/Eif4ebp1tm1Nso
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4ebp1tm1Nso mutation (2 available); any Eif4ebp1 mutation (33 available)
Rhebtm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:197831 )
• improved survival compared to in Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds mice

cardiovascular system
cardiovascular system phenotype ( J:197831 )
N
• mice exhibit improved cardiac function, hypertrophic growth and sarcomere maturation compared with Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds mice




Genotype
MGI:5502749
cn4
Allelic
Composition		 Atg5tm1Myok/Atg5tm1Myok
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg5tm1Myok mutation (3 available); any Atg5 mutation (29 available)
Rhebtm1.1Otsu mutation (0 available); any Rheb mutation (26 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory