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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasd1tm1.1Snyd
targeted mutation 1.1, Solomon Snyder
MGI:5502750
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasd1tm1.1Snyd/Rasd1tm1.1Snyd involves: C57BL/6 MGI:5502751


Genotype
MGI:5502751
hm1
Allelic
Composition		 Rasd1tm1.1Snyd/Rasd1tm1.1Snyd
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasd1tm1.1Snyd mutation (0 available); any Rasd1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:195135 )
• NMDA-treated primary neurons do not exhibit reduced cell viability
• NMDA-treated retinal ganglion cells do not exhibit cell loss
abnormal iron homeostasis ( J:195135 )
• NMDA-treated cortical cultures fail to exhibit an increase in iron uptake unlike wild-type cells
• however, iron efflux in primary neurons is not affected

cellular
decreased susceptibility to neuronal excitotoxicity ( J:195135 )
• NMDA-treated primary neurons do not exhibit reduced cell viability
• NMDA-treated retinal ganglion cells do not exhibit cell loss

nervous system
decreased susceptibility to neuronal excitotoxicity ( J:195135 )
• NMDA-treated primary neurons do not exhibit reduced cell viability
• NMDA-treated retinal ganglion cells do not exhibit cell loss




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory