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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sh2d1atm1.1Knic
targeted mutation 1.1, Kim E Nichols
MGI:5502752
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sh2d1atm1.1Knic/Sh2d1atm1.1Knic
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * 129X1/SvJ * C57BL/6 MGI:5502763
cn2
 		Sh2d1atm1.1Knic/Y
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0 		involves: 129S/SvEv * 129X1/SvJ * C57BL/6 MGI:5502766


Genotype
MGI:5502763
cn1
Allelic
Composition		 Sh2d1atm1.1Knic/Sh2d1atm1.1Knic
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (993 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
Sh2d1atm1.1Knic mutation (0 available); any Sh2d1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:196692 )
N
• tamoxifen-treated mice exhibit normal invariant NKT cell numbers, phenotype and in vivo responsiveness to lipid antigens
abnormal NK T cell physiology ( J:196692 )
• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site
decreased circulating interleukin-4 level ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets
decreased interferon-gamma secretion ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets

homeostasis/metabolism
decreased circulating interleukin-4 level ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets

hematopoietic system
abnormal NK T cell physiology ( J:196692 )
• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site




Genotype
MGI:5502766
cn2
Allelic
Composition		 Sh2d1atm1.1Knic/Y
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic
Background		 involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (993 available)
Ndor1Tg(UBC-cre/ERT2)1Ejb mutation (6 available); any Ndor1 mutation (32 available)
Sh2d1atm1.1Knic mutation (0 available); any Sh2d1a mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:196692 )
N
• tamoxifen-treated mice exhibit normal invariant NKT cell numbers, phenotype and in vivo responsiveness to lipid antigens
abnormal NK T cell physiology ( J:196692 )
• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site
decreased circulating interleukin-4 level ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets
decreased interferon-gamma secretion ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets

homeostasis/metabolism
decreased circulating interleukin-4 level ( J:196692 )
• from iNKT cells from tamoxifen-treated mice in response to EL4 targets

hematopoietic system
abnormal NK T cell physiology ( J:196692 )
• in vitro TCR-induced invariant NKT (iNKT) cell cytotoxicity from tamoxifen-treated mice is impaired compared to in control cells
• iNKT cells from tamoxifen-treated mice exhibit impaired control of tumor growth in vivo compared with control cells
• in response to EL4 targets, iNKT cells from tamoxifen-treated mcie form fewer conjugates and produce reduced levels of cytokines (IFN-gamma and IL4) compared with control cells
• however, iNKT cells exhibit normal trafficking to the tumor site




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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory