Phenotypes associated with this allele

• Allele Symbol: Alx4^M1Yzcm
• Allele Name: mutation 1, Yangzhou University Comparative Medicine Center
• Allele ID: MGI:5502864
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Alx4^M1Yzcm/Alx4^M1Yzcm	C57BL/6-Alx4^M1Yzcm	MGI:5502883
ht2	Alx4^M1Yzcm/Alx4^+	C57BL/6-Alx4^M1Yzcm	MGI:5502882

Genotype
MGI:5502883

hm1

• Allelic Composition: Alx4^M1Yzcm/Alx4^M1Yzcm
• Genetic Background: C57BL/6-Alx4^M1Yzcm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:199512 )

• most mice are non-viable after birth

growth/size/body

abnormal abdominal wall morphology ( J:199512 )

• lack of ventral abdominal wall musculature and thin skin in the region at E19.5

herniated abdominal wall ( J:199512 )

omphalocele ( J:199512 )

skeleton

small parietal bone ( J:199512 )

short tibia ( J:199512 )

absent pubis ( J:199512 )

vision/eye

eyelids open at birth ( J:199512 )

craniofacial

small parietal bone ( J:199512 )

integument

alopecia ( J:199512 )

• in surviving mice

thin skin ( J:199512 )

• thin skin on the ventral abdominal wall at E19.5

muscle

abnormal muscle morphology ( J:199512 )

• lack of ventral abdominal wall musculature at E19.5

limbs/digits/tail

preaxial polydactyly ( J:199512 )

• extensive on all limbs

short tibia ( J:199512 )

Genotype
MGI:5502882

ht2

• Allelic Composition: Alx4^M1Yzcm/Alx4⁺
• Genetic Background: C57BL/6-Alx4^M1Yzcm

limbs/digits/tail

preaxial polydactyly ( J:199512 )

• in one hindlimb, rarely in both