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Allele Symbol Allele Name Allele ID |
Tslptm1Sfz targeted mutation 1, Steven Ziegler MGI:5503051 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice sensitized in the skin with TSLP and ovalbumin and challenged intranasally with ovalbumin exhibit a robust response as in control mice
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| N |
• mice sensitized in the skin with TSLP and ovalbumin and challenged intranasally with ovalbumin exhibit a robust response as in control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exposed to ovalbumin and restimulated exhibit early impairment in Th2 response (IL5 and IL13 cytokine production) compared with control mice
• however, mice exhibit normal later stages of allergen-induced responses and allergic airway response or Th2 immunity
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• mice exposed to ovalbumin and restimulated exhibit impaired Th2 cytokine (IL5 and IL13) production compared with control mice
• however, previously skewed T cell population exhibit normal Th2 cytokine productions
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• from ovalbumin restimulated lung draining lymph nodes
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• from ovalbumin restimulated lung draining lymph nodes
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• mice exposed to ovalbumin and restimulated exhibit early impairment in Th2 response (IL5 and IL13 cytokine production) compared with control mice
• however, mice exhibit normal later stages of allergen-induced responses and allergic airway response or Th2 immunity
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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