Phenotypes associated with this allele

• Allele Symbol: Itsn2^tm1Egan
• Allele Name: targeted mutation 1, Sean Egan
• Allele ID: MGI:5503193
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itsn2^tm1Egan/Itsn2^tm1Egan	Not Specified	MGI:5503220
cx2	Itsn1^Gt(pT1ATGBetageo)1Ruiz/Itsn1^Gt(pT1ATGBetageo)1Ruiz Itsn2^tm1Egan/Itsn2^tm1Egan	involves: 129S2/SvPas	MGI:5503964

Genotype
MGI:5503220

hm1

• Allelic Composition: Itsn2^tm1Egan/Itsn2^tm1Egan
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:196062 )

N • mice exhibit normal brains morphology, hippocampal synaptic transmission and plasticity

behavior/neurological

behavior/neurological phenotype ( J:196062 )

N • mice exhibit normal behavior

Genotype
MGI:5503964

cx2

• Allelic Composition: Itsn1^{Gt(pT1ATGBetageo)1Ruiz}/Itsn1^{Gt(pT1ATGBetageo)1Ruiz}; Itsn2^tm1Egan/Itsn2^tm1Egan
• Genetic Background: involves: 129S2/SvPas

behavior/neurological

impaired contextual conditioning behavior ( J:196062 )

• mice exhibit less freezing compared with wild-type mice

abnormal spatial learning ( J:196062 )

• in a Morris water maze, mice fail to learn the location of a hidden platform and fail to exhibit a strong spatial bias for the zone where the platform was located unlike wild-type mice

impaired coordination ( J:196062 )

• impaired bimanual motor coordination in a grid test that is worse than in Itsn1^{Gt(pT1ATGBetageo)1Ruiz} homozygotes

nervous system

abnormal brain white matter morphology ( J:196062 )

• the corpus callosum, ventral hippocampal commissure and anterior commissure exhibit a loss of fiber tracts compared with control mice

abnormal corpus callosum morphology ( J:196062 )

• lack of midline

growth/size/body

decreased body weight ( J:196062 )

• as in Itsn1^{Gt(pT1ATGBetageo)1Ruiz} homozygotes