Phenotypes associated with this allele

• Allele Symbol: Ifne^tm1.2Pjh
• Allele Name: targeted mutation 1.2, Paul J Hertzog
• Allele ID: MGI:5503222
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifne^tm1.2Pjh/Ifne^tm1.2Pjh	involves: C57BL/6	MGI:5503228

Genotype
MGI:5503228

hm1

• Allelic Composition: Ifne^tm1.2Pjh/Ifne^tm1.2Pjh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:197569 )

N • male and female mice exhibit normal fertility

immune system

decreased NK cell number ( J:197569 )

• in Chlamydia infected mice

increased susceptibility to bacterial infection ( J:197569 )

• mice infected with Chlamydia muridarum exhibit more severe clinical signs of disease with increased bacterial load and decreased NK cell numbers compared with wild-type mice

increased susceptibility to Herpesvirales infection ( J:197569 )

• mice infected with HSV-2 strain 186 exhibit more severe clinical scores of disease (genital lesions, redness and swelling) with severe epidermal lesions and increased viral titers in infected vaginal tissues, spinal cord and brain stem compared with wild-type mice

integument

skin lesions ( J:197569 )

• severe epidermal lesions in mice infected with HSV-2 strain 186

hematopoietic system

decreased NK cell number ( J:197569 )

• in Chlamydia infected mice