Analysis Tools
cellular
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• three fold increase in micronuclei and nucleoplasmic bridges after etoposide treatment as compared to controls
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• three fold increase in chromosomal aberrations after etoposide treatment as compared to controls
• increased number of chromosomal breaks and exchanges in metaphase spreads of mice treated with etoposide
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• severe reduction of metaphase spreads in cultured embryonic fibroblasts treated with etoposide
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homeostasis/metabolism
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• are hypersensitive to etoposide damage but sensitivity is normal to gamma radiation
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growth/size/body
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• etoposide causes a progressive and severe weight loss unlike the transient weight loss seen in controls
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digestive/alimentary system
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• villous atrophy 6 days after treatment with etoposide
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hematopoietic system
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• reduced cellular content after etoposide treatment
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• 30-50% loss of pro-B cells, 95%loss of pre-B cells and immature B cell precursors
• losses are not significantly different from controls similarly treated with etoposide
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• almost completely eliminated by etoposide treatment
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• two fold increase relative to controls in micronucleated polychromatic erythrocytes in bone marrow from etoposide treated mice
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• reduced cellular content after etoposide treatment
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immune system
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• 30-50% loss of pro-B cells, 95%loss of pre-B cells and immature B cell precursors
• losses are not significantly different from controls similarly treated with etoposide
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• almost completely eliminated by etoposide treatment
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• reduced cellular content after etoposide treatment
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• reduced cellular content after etoposide treatment
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endocrine/exocrine glands
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• reduced cellular content after etoposide treatment
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