Phenotypes associated with this allele

• Allele Symbol: Slc5a10^tm1Csk
• Allele Name: targeted mutation 1, Chugai Pharmaceutical Co, Ltd
• Allele ID: MGI:5503305
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc5a10^tm1Csk/Slc5a10^tm1Csk	C57BL/6-Slc5a10^tm1Csk	MGI:5503308

Genotype
MGI:5503308

hm1

• Allelic Composition: Slc5a10^tm1Csk/Slc5a10^tm1Csk
• Genetic Background: C57BL/6-Slc5a10^tm1Csk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increase in liver triglyceride levels in Slc5a10^tm1Csk/Slc5a10^tm1Csk mice fed a high fructose diet

homeostasis/metabolism

increased circulating insulin level ( J:199406 )

• in mice fed a high fructose diet

decreased circulating triglyceride level ( J:199406 )

• in mice fed a high fructose diet

increased circulating alanine transaminase level ( J:199406 )

• in mice fed a high fructose diet

increased circulating aspartate transaminase level ( J:199406 )

• in mice fed a high fructose diet

increased circulating lactate dehydrogenase level ( J:199406 )

• in mice fed a high fructose diet

increased circulating serum albumin level ( J:199406 )

• in mice fed a high fructose diet

increased liver triglyceride level ( J:199406 )

• in mice fed a high fructose diet

abnormal urine homeostasis ( J:199406 )

• increased urinary fructose in mice fed fructose water

liver/biliary system

increased liver weight ( J:199406 )

• in mice fed a high fructose diet

increased liver triglyceride level ( J:199406 )

• in mice fed a high fructose diet

hepatic steatosis ( J:199406 )

• in mice fed a high fructose diet

renal/urinary system

abnormal urine homeostasis ( J:199406 )

• increased urinary fructose in mice fed fructose water

abnormal renal reabsorption ( J:199406 )

• brush border membrane vesicles exhibit impaired sodium-dependent fructose and mannose uptake compared with wild-type mice

• however, sodium-independent fructose and mannose uptake is normal

adipose tissue

decreased epididymal fat pad weight ( J:199406 )

• in mice fed a high fructose diet

growth/size/body

increased liver weight ( J:199406 )

• in mice fed a high fructose diet