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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl3tm1Kei
targeted mutation 1, Keiichi I Nakayama
MGI:5503966
Summary 2 genotypes


Genotype
MGI:5503968
hm1
Allelic
Composition		 Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic
Background		 B6.129P2-Fbxl3tm1Kei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl3tm1Kei mutation (1 available); any Fbxl3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
prolonged circadian behavior period ( J:196293 )
• when mice are kept in constant darkness, free-running period is increased compared to in wild-type mice
abnormal circardian behavior entrainment ( J:196293 )
• when mice are entrained to a 12L:12D cycle (LD), the onset of active phase is delayed from the light-to-dark transition compared to in wild-type mice
• when transferred from constant darkness (DD) to LD, mice fail to entrain and free run as in DD




Genotype
MGI:5503970
cx2
Allelic
Composition		 Fbxl21tm1Kei/Fbxl21tm1Kei
Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic
Background		 B6.129P2-Fbxl21tm1Kei Fbxl3tm1Kei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl21tm1Kei mutation (1 available); any Fbxl21 mutation (26 available)
Fbxl3tm1Kei mutation (1 available); any Fbxl3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal circadian behavior ( J:196293 )
• unstable behavior rhythm in constant darkness




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory