All Phenotypes Nf2<tm2Gvn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nf2^tm2Gvn
targeted mutation 2, Marco Giovannini
MGI:5504370

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nf2^tm2Gvn/Nf2^tm2Gvn	Not Specified	MGI:5504374
ht2	Nf2^tm2Gvn/Nf2⁺	Not Specified	MGI:5504375

Allelic Composition	Nf2^tm2Gvn/Nf2^tm2Gvn
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf2^tm2Gvn mutation (1 available); any Nf2 mutation (65 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:197562 )

• axons exhibit smaller diameters, shrinkage and reduced interfilament distances compared to in wild-type mice

• sciatic nerve axons exhibit misshapen and dysmorphic axons and accumulation of neurofilaments and mitochondria compared with wild-type sciatic nerves

• however, the total number of axons and overall axon caliber

abnormal action potential ( J:197562 )

• reduced compound muscle action potential amplitudes compared with wild-type mice

• however, nerve conduction velocities are normal

behavior/neurological

impaired coordination ( J:197562 )

• reduced latency to fall from a rotarod

increased thermal nociceptive threshold ( J:197562 )

• in a hot plate test

Allelic Composition	Nf2^tm2Gvn/Nf2⁺
Genetic Background	Not Specified