All Phenotypes Map2k1<tm1.1Bacc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k1^tm1.1Bacc
targeted mutation 1.1, Manuela Baccarini
MGI:5504393

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	129-Map2k1^tm1.1Bacc	MGI:5504402
hm2	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	either: 129-Map2k1^tm1.1Bacc or (involves: 129P2/OlaHsd * C57BL/6)	MGI:5504403
hm3	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	involves: 129P2/OlaHsd * C57BL/6	MGI:5504401
cn4	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Meox2^tm1(cre)Sor/Meox2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:5504404
cn5	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5504406
cn6	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5504405

Allelic Composition	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
Genetic Background	129-Map2k1^tm1.1Bacc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199705 )

• mice die around E9.5

Allelic Composition	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
Genetic Background	either: 129-Map2k1^tm1.1Bacc or (involves: 129P2/OlaHsd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent ectoplacental cone ( J:199705 )

abnormal trophoblast layer morphology ( J:199705 )

• thin

Allelic Composition	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199705 )

• mice die around E9.5

Allelic Composition	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k1^tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)
Map2k1^tm1Bacc mutation (2 available); any Map2k1 mutation (94 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:199705 )

N	• embryonic lethality observed in Map2k1^tm1.1Bacc homozygotes is rescued

Allelic Composition	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Map2k1^tm1.1Bacc mutation (0 available); any Map2k1 mutation (94 available)
Map2k1^tm1Bacc mutation (2 available); any Map2k1 mutation (94 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:199705 )

• mice do not exhibit any obvious phenotypes

Allelic Composition	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

postnatal growth retardation ( J:199705 )

• slight after P20

nervous system

nervous system phenotype ( J:199705 )

N	• mice exhibit normal gross brain, central and peripheral nervous system anatomy

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