Phenotypes associated with this allele

• Allele Symbol: Map2k1^tm1.1Bacc
• Allele Name: targeted mutation 1.1, Manuela Baccarini
• Allele ID: MGI:5504393
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	129-Map2k1^tm1.1Bacc	MGI:5504402
hm2	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	either: 129-Map2k1^tm1.1Bacc or (involves: 129P2/OlaHsd * C57BL/6)	MGI:5504403
hm3	Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc	involves: 129P2/OlaHsd * C57BL/6	MGI:5504401
cn4	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Meox2^tm1(cre)Sor/Meox2^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:5504404
cn5	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5504406
cn6	Map2k1^tm1Bacc/Map2k1^tm1.1Bacc Tg(Nes-cre)1Kln/0	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5504405

Genotype
MGI:5504402

hm1

• Allelic Composition: Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
• Genetic Background: 129-Map2k1^tm1.1Bacc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199705 )

• mice die around E9.5

Genotype
MGI:5504403

hm2

• Allelic Composition: Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
• Genetic Background: either: 129-Map2k1^tm1.1Bacc or (involves: 129P2/OlaHsd * C57BL/6)

embryo

absent ectoplacental cone ( J:199705 )

abnormal trophoblast layer morphology ( J:199705 )

• thin

Genotype
MGI:5504401

hm3

• Allelic Composition: Map2k1^tm1.1Bacc/Map2k1^tm1.1Bacc
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:199705 )

• mice die around E9.5

Genotype
MGI:5504404

cn4

• Allelic Composition: Map2k1^tm1Bacc/Map2k1^tm1.1Bacc; Meox2^tm1(cre)Sor/Meox2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

mortality/aging

mortality/aging ( J:199705 )

N • embryonic lethality observed in Map2k1^tm1.1Bacc homozygotes is rescued

Genotype
MGI:5504406

cn5

• Allelic Composition: Map2k1^tm1Bacc/Map2k1^tm1.1Bacc; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:199705 )

• mice do not exhibit any obvious phenotypes

Genotype
MGI:5504405

cn6

• Allelic Composition: Map2k1^tm1Bacc/Map2k1^tm1.1Bacc; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

growth/size/body

postnatal growth retardation ( J:199705 )

• slight after P20

nervous system

nervous system phenotype ( J:199705 )

N • mice exhibit normal gross brain, central and peripheral nervous system anatomy