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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smarcc2tm1.1Stoy
targeted mutation 1.1, Anastassia Stoykova
MGI:5504428
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy involves: 129S1/Sv * C57BL/6 MGI:5504439
cn2
 		Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy involves: 129S1/Sv * C57BL/6 MGI:5504441
cn3
 		Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:5504445
cn4
 		Pax6tm2Pgr/Pax6tm2Pgr
Smarcc2tm1.1Stoy/Smarcc2+
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:5504443
cn5
 		Pax6tm2Pgr/Pax6tm2Pgr
Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Emx1tm1(cre)Krj/Emx1+ 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 MGI:5504444
cn6
 		Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Neurod6tm1(cre)Kan/Neurod6+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5504446


Genotype
MGI:5504439
hm1
Allelic
Composition		 Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:197141 )
• mice are viable and fertile with no apparent abnormalities




Genotype
MGI:5504441
cn2
Allelic
Composition		 Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal precursor proliferation ( J:197141 )
• in E13.5 brains electroporated with a cre-expressing plasmid, radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons

cellular
abnormal neuronal precursor proliferation ( J:197141 )
• in E13.5 brains electroporated with a cre-expressing plasmid, radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons




Genotype
MGI:5504445
cn3
Allelic
Composition		 Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:197141 )
• increase in indirect neurogenesis
• however, neuron migration and apoptosis are normal
abnormal neuronal precursor proliferation ( J:197141 )
• radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
• however, proliferative capacity of intermediate progenitors is normal
abnormal neocortex morphology ( J:197141 )
• increased volume, surface area, anterior-posterior dimension and dorsoventral dimension
thickened cerebral cortex ( J:197141 )
• in the rostral, intermediate and caudal areas
abnormal neuronal precursor cell number ( J:197141 )
• twice as many nonapical pHH3+ (mitotic marker) cells in the cortex at E14.5
• increased Tbr2+ cells in the subventricular zone at E12.5 with progressive increase between E13.5 and E15.5

cellular
abnormal neuron differentiation ( J:197141 )
• increase in indirect neurogenesis
• however, neuron migration and apoptosis are normal
abnormal neuronal precursor proliferation ( J:197141 )
• radial glial progenitors are biased to asymmetric nonneurogenic divisions and the production of intermediate progenitors instead of neurons
• however, proliferative capacity of intermediate progenitors is normal
abnormal DNA methylation ( J:197141 )
• decreased CpG methylation on Cux1 and Tie1 promoters




Genotype
MGI:5504443
cn4
Allelic
Composition		 Pax6tm2Pgr/Pax6tm2Pgr
Smarcc2tm1.1Stoy/Smarcc2+
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (94 available)
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:197141 )
N
• mice exhibit normal cortical surface at P8 and numbers of Tbr2+ intermediate progenitors at E14.5
abnormal neuron number ( J:197141 )
• mice exhibit increased production of Cux1+ upper layer identity neurons




Genotype
MGI:5504444
cn5
Allelic
Composition		 Pax6tm2Pgr/Pax6tm2Pgr
Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Emx1tm1(cre)Krj/Emx1+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Pax6tm2Pgr mutation (1 available); any Pax6 mutation (94 available)
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neocortex morphology ( J:197141 )
• decreased cortical surface at P8
abnormal neuron number ( J:197141 )
• reduced of Cux1+ upper layer identity neurons
abnormal neuronal precursor cell number ( J:197141 )
• decreased Tbr2+ cells in E14.5 dorsal cortex




Genotype
MGI:5504446
cn6
Allelic
Composition		 Smarcc2tm1.1Stoy/Smarcc2tm1.1Stoy
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
Smarcc2tm1.1Stoy mutation (0 available); any Smarcc2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:197141 )
N
• the number of cortical progenitors and neuronal production is normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory