Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy
• Allele Name: transgene insertion, Anastassia Stoykova
• Allele ID: MGI:5504430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Emx1^tm1(cre)Krj/Emx1^+ Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0	involves: 129S2/SvPas	MGI:5504448

Genotype
MGI:5504448

cn1

• Allelic Composition: Emx1^tm1(cre)Krj/Emx1⁺; Tg(CMV-GFP,-Smarcc2,-lacZ)#Stoy/0
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:197141 )

• direct increase in neurogenesis

abnormal neocortex morphology ( J:197141 )

• decreased volume, surface area, anterior-posterior dimension and dorsoventral dimension

thin cerebral cortex ( J:197141 )

• thin cerebral cortex in the rostral, intermediate and caudal areas

• at P10, radial thickness is reduced that more severely affects the width of the upper layers and a slight increase in neuronal density at L6 compared with control mice

abnormal neuron number ( J:197141 )

• increase number of Tuj1+ neurons in the early cortical plate with subsequent decrease at E14.5 to E15.5

abnormal neuronal precursor cell number ( J:197141 )

• decreased Tbr2+ intermediate progenitor cells at E12.5 to E13

cellular

abnormal neuron differentiation ( J:197141 )

• direct increase in neurogenesis

abnormal DNA methylation ( J:197141 )

• increased CpG methylation on Cux1 and Tie1 promoters