Phenotypes associated with this allele

• Allele Symbol: Ctnna3^tm1.1Fvr
• Allele Name: targeted mutation 1.1, Frans van Roy
• Allele ID: MGI:5504493
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctnna3^tm1.1Fvr/Ctnna3^tm1.1Fvr	involves: 129S6/SvEvTac * BALB/cJ	MGI:5504498

Genotype
MGI:5504498

hm1

• Allelic Composition: Ctnna3^tm1.1Fvr/Ctnna3^tm1.1Fvr
• Genetic Background: involves: 129S6/SvEvTac * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:197814 )

• in 2 of 21 mice following ischemia-reperfusion injury

cardiovascular system

abnormal myocardial fiber morphology ( J:197814 )

• number and size of Cx43+ gap junctions are decreased compared to in wild-type mice

increased heart weight ( J:197814 )

• modestly at 3 months

abnormal heart left ventricle morphology ( J:197814 )

• increased internal dimension at the end of systole and diastole at 3 months

increased heart ventricle size ( J:197814 )

• slightly at 6 months without fibrosis

dilated cardiomyopathy ( J:197814 )

• early onset

decreased cardiac muscle contractility ( J:197814 )

• decreased ejection fraction and fraction shortening at 3 months

irregular heartbeat ( J:197814 )

• mice exhibit increased susceptibility to ischemia-induced arrhythmias compared with wild-type mice

muscle

abnormal myocardial fiber morphology ( J:197814 )

• number and size of Cx43+ gap junctions are decreased compared to in wild-type mice

dilated cardiomyopathy ( J:197814 )

• early onset

decreased cardiac muscle contractility ( J:197814 )

• decreased ejection fraction and fraction shortening at 3 months

growth/size/body

increased heart weight ( J:197814 )

• modestly at 3 months