Phenotypes associated with this allele

• Allele Symbol: Pcdhg^tm1.2Sch
• Allele Name: targeted mutation 1.2, Martin K Schwarz
• Allele ID: MGI:5504505
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pcdhg^tm1.2Sch/Pcdhg^tm1.2Sch	B6.129-Pcdhg^tm1.2Sch	MGI:5504531

Genotype
MGI:5504531

cn1

• Allelic Composition: Pcdhg^tm1.2Sch/Pcdhg^tm1.2Sch
• Genetic Background: B6.129-Pcdhg^tm1.2Sch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:195283 )

N • a lentivirus construct expressing cre and EGFP is injected into the subventricular zone of neonatal mice. B type stem cells, C type transit amplifying cells, and A type neuroblasts are infected

abnormal olfactory bulb development ( J:195283 )

• abnormal development of infected cells that have migrated to the olfactory bulb by 14 days after infection

• fewer cells reach the olfactory bulb from the subventricular zone

• cells reaching the olfactory bulb have acquired a neuronal identity

abnormal dendrite morphology ( J:195283 )

• decreased apical dendrite length in granule cells by 42 days after infection

• reduced dendritic branching

• reduced arbor complexity starting at 14 days after infection

decreased dendritic spine number ( J:195283 )

• significantly reduced spine number on dendrites of granule cells of the olfactory bulb