mortality/aging
• no living fetuses are recovered at E14.5
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• lethality is observed beginning at E11.5, increasing as development progresses
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cardiovascular system
• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2tm1Ypc homozygous embryos
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muscle
• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2tm1Ypc homozygous embryos
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