About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P4hbtm1.1Geno
targeted mutation 1.1, Genoway
MGI:5504624
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Pf4-icre)Q3Rsko/0 		involves: 129 * C57BL/6 MGI:6377675
cn2
 		P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Mx1-cre)1Cgn/0 		involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:6377674
cn3
 		P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:5504638


Genotype
MGI:6377675
cn1
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Pf4-icre)Q3Rsko/0
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (32 available)
Tg(Pf4-icre)Q3Rsko mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased platelet aggregation ( J:229395 )
• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury
• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect
abnormal platelet dense granule physiology ( J:229395 )
• ATP secretion from dense granules of platelets is about 50% of the normal platelets
decreased susceptibility to induced thrombosis ( J:229395 )
• the time to complete occlusion after FeCl3-induced injury of the carotid artery is doubled
• incorporation of platelets into a thrombus in a FeCL3-induced mesenteric artery thrombosis model is decreased
• however, platelets do not have a defect in fibrin deposition at sites of injury
increased bleeding time ( J:229395 )
• tail bleeding times are approximately doubled

hematopoietic system
hematopoietic system phenotype ( J:229395 )
N
• complete blood counts show no abnormalities and platelet counts and size are normal
decreased platelet aggregation ( J:229395 )
• mice have a defect in platelet accumulation at sites of laser-induced cremaster arteriole injury
• thrombin- and convulxin-induced aggregation of platelets is decreased, however higher doses of thrombin or convulxin overcome the aggregation defect
abnormal platelet dense granule physiology ( J:229395 )
• ATP secretion from dense granules of platelets is about 50% of the normal platelets




Genotype
MGI:6377674
cn2
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.1Geno
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (32 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased platelet aggregation ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury
decreased susceptibility to induced thrombosis ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation and fibrin deposition at sites of laser-induced cremaster arteriole injury

hematopoietic system
hematopoietic system phenotype ( J:229395 )
N
• poly(I:C)-treated mice exhibit normal blood counts and platelet counts are comparable to controls although slightly lower after poly(I:C) and platelet size is comparable to controls
decreased platelet aggregation ( J:229395 )
• poly(I:C)-treated mice show defects in platelet accumulation at sites of injury laser-induced cremaster arteriole injury




Genotype
MGI:5504638
cn3
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (32 available)
P4hbtm1.2Geno mutation (0 available); any P4hb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells

hematopoietic system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory