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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P4hbtm1.2Geno
targeted mutation 1.2, Genoway
MGI:5504625
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd MGI:5504638


Genotype
MGI:5504638
cn1
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (32 available)
P4hbtm1.2Geno mutation (0 available); any P4hb mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells

hematopoietic system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory