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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ralatm1.1Cjm
targeted mutation 1.1, Christopher J Marshall
MGI:5505277
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ralatm1.1Cjm/Ralatm1.1Cjm involves: C57BL/6 * C57BL/6J MGI:5505286
cx2
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+ 		involves: C57BL/6 * C57BL/6J MGI:5505289
cx3
 		Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505290
cx4
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505291


Genotype
MGI:5505286
hm1
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
exencephaly ( J:199742 )
• in 10 of 33 mice between E15.5 and E19.5

cellular
cellular phenotype ( J:199742 )
N
• mouse embryonic fibroblasts exhibit normal proliferation




Genotype
MGI:5505289
cx2
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (28 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally

growth/size/body
embryonic growth retardation ( J:199742 )

nervous system
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally




Genotype
MGI:5505290
cx3
Allelic
Composition		 Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (28 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:199742 )
N
• normal neural tube development

growth/size/body
embryonic growth retardation ( J:199742 )
• in some mice

nervous system
nervous system phenotype ( J:199742 )
N
• normal neural tube development




Genotype
MGI:5505291
cx4
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (28 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:199742 )
• no mice are detected between E10.5 and E13.5




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory