About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ralbtm1.1Cjm
targeted mutation 1.1, Christopher J Marshall
MGI:5505278
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ralbtm1.1Cjm/Ralbtm1.1Cjm involves: C57BL/6 * C57BL/6J MGI:5505292
cn2
 		Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5505293
cn3
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505287
cx4
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+ 		involves: C57BL/6 * C57BL/6J MGI:5505289
cx5
 		Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505290
cx6
 		Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505291


Genotype
MGI:5505292
hm1
Allelic
Composition		 Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:199742 )
• mice displayed no obvious abnormalities including normal DMBA-TPA-induced tumor formation




Genotype
MGI:5505293
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
Ralbtm1.2Cjm mutation (2 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:199742 )
• in a model of non-small cell lung carcinoma, mice exposed to a cre-expressing adenovirus exhibit fewer tumors and smaller tumor area compared with Krastm4Tyj/Kras+ Ralatm1.2Cjm/Rala+ Ralbtm1.1Cjm/Ralbtm1.2Cjm control mice




Genotype
MGI:5505287
cn3
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:199742 )
• in mouse embryonic fibroblasts infected with a cre-expressing adenovirus




Genotype
MGI:5505289
cx4
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralb+
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally

growth/size/body
embryonic growth retardation ( J:199742 )

nervous system
abnormal neural tube morphology ( J:199742 )
• severe in all mice at E10.5 to E13.5
open neural tube ( J:199742 )
• at the forebrain/midbrain boundary, hindbrain/cervical boundary and caudally




Genotype
MGI:5505290
cx5
Allelic
Composition		 Ralatm1.1Cjm/Rala+
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryo phenotype ( J:199742 )
N
• normal neural tube development

growth/size/body
embryonic growth retardation ( J:199742 )
• in some mice

nervous system
nervous system phenotype ( J:199742 )
N
• normal neural tube development




Genotype
MGI:5505291
cx6
Allelic
Composition		 Ralatm1.1Cjm/Ralatm1.1Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.1Cjm mutation (0 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:199742 )
• no mice are detected between E10.5 and E13.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory