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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ralatm1.2Cjm
targeted mutation 1.2, Christopher J Marshall
MGI:5505279
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J MGI:5505293
cn2
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505287
cn3
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.2Cjm/Ralbtm1.2Cjm 		involves: C57BL/6 * C57BL/6J MGI:5505288
cn4
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Tg(Fabp4-cre)1Rev/0 		involves: C57BL/6 * C57BL/6J MGI:5505296
cn5
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.2Cjm/Ralbtm1.2Cjm
Tg(Fabp4-cre)1Rev/0 		involves: C57BL/6 * C57BL/6J MGI:5505298
cn6
 		Ralatm1.2Cjm/Ralatm1.2Cjm
Tg(KRT14-cre)8Brn/0 		involves: C57BL/6 * C57BL/6J * FVB/N MGI:5505294


Genotype
MGI:5505293
cn1
Allelic
Composition		 Krastm4Tyj/Kras+
Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.2Cjm
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
Ralbtm1.2Cjm mutation (2 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:199742 )
• in a model of non-small cell lung carcinoma, mice exposed to a cre-expressing adenovirus exhibit fewer tumors and smaller tumor area compared with Krastm4Tyj/Kras+ Ralatm1.2Cjm/Rala+ Ralbtm1.1Cjm/Ralbtm1.2Cjm control mice




Genotype
MGI:5505287
cn2
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.1Cjm/Ralbtm1.1Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.1Cjm mutation (0 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased fibroblast proliferation ( J:199742 )
• in mouse embryonic fibroblasts infected with a cre-expressing adenovirus




Genotype
MGI:5505288
cn3
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.2Cjm/Ralbtm1.2Cjm
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.2Cjm mutation (2 available); any Ralb mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:199742 )
N
• mouse embryonic fibroblasts infected with a cre-expressing adenovirus exhibit normal proliferation




Genotype
MGI:5505296
cn4
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Tg(Fabp4-cre)1Rev/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Tg(Fabp4-cre)1Rev mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:199742 )
N
• mice exhibit normal viability




Genotype
MGI:5505298
cn5
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Ralbtm1.2Cjm/Ralbtm1.2Cjm
Tg(Fabp4-cre)1Rev/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Ralbtm1.2Cjm mutation (2 available); any Ralb mutation (47 available)
Tg(Fabp4-cre)1Rev mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5505294
cn6
Allelic
Composition		 Ralatm1.2Cjm/Ralatm1.2Cjm
Tg(KRT14-cre)8Brn/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ralatm1.2Cjm mutation (2 available); any Rala mutation (27 available)
Tg(KRT14-cre)8Brn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:199742 )
N
• DMBA-TPA-treated mice exhibit normal tumor formation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory