All Phenotypes Igk<tm1.1(b12)Nemz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igk^{tm1.1(b12)Nemz}
targeted mutation 1.1, David Nemazee
MGI:5505300

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igk^{tm1.1(b12)Nemz}/Igk^{tm1.1(b12)Nemz}	involves: C57BL/6NTac * FVB/N	MGI:5550084
cx2	Igh^{tm1.1(b12)Nemz}/Igh^{tm1.1(b12)Nemz} Igk^{tm1.1(b12)Nemz}/Igk^{tm1.1(b12)Nemz}	involves: C57BL/6N * C57BL/6NTac * FVB/N	MGI:5550085

Allelic Composition	Igk^{tm1.1(b12)Nemz}/Igk^{tm1.1(b12)Nemz}
Genetic Background	involves: C57BL/6NTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igk^{tm1.1(b12)Nemz} mutation (1 available); any Igk mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205766 )

N	• mice produce normal levels of IgM and B cell numbers

Allelic Composition	Igh^{tm1.1(b12)Nemz}/Igh^{tm1.1(b12)Nemz} Igk^{tm1.1(b12)Nemz}/Igk^{tm1.1(b12)Nemz}
Genetic Background	involves: C57BL/6N * C57BL/6NTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^{tm1.1(b12)Nemz} mutation (1 available); any Igh mutation (44 available)
Igk^{tm1.1(b12)Nemz} mutation (1 available); any Igk mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:205766 )

N	• B cells exhibit normal development, recognize HIV antigens, trigger normally and produce high levels of b12 IgG in serum

decreased immature B cell number ( J:205766 )

• in the bone marrow

increased B cell number ( J:205766 )

• in the lymph node

decreased IgM level ( J:205766 )

• slightly

hematopoietic system