Phenotypes associated with this allele

• Allele Symbol: Igh^{tm1.1(b12)Nemz}
• Allele Name: targeted mutation 1.1, David Nemazee
• Allele ID: MGI:5505302
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1(b12)Nemz/Igh^tm1.1(b12)Nemz	involves: C57BL/6N * FVB/N	MGI:5550083
cx2	Igh^tm1.1(b12)Nemz/Igh^tm1.1(b12)Nemz Igk^tm1.1(b12)Nemz/Igk^tm1.1(b12)Nemz	involves: C57BL/6N * C57BL/6NTac * FVB/N	MGI:5550085

Genotype
MGI:5550083

hm1

• Allelic Composition: Igh^{tm1.1(b12)Nemz}/Igh^{tm1.1(b12)Nemz}
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immature B cell number ( J:205766 )

• in the bone marrow

increased B cell number ( J:205766 )

• in the lymph node

decreased IgM level ( J:205766 )

• slightly

hematopoietic system

decreased immature B cell number ( J:205766 )

• in the bone marrow

increased B cell number ( J:205766 )

• in the lymph node

decreased IgM level ( J:205766 )

• slightly

Genotype
MGI:5550085

cx2

• Allelic Composition: Igh^{tm1.1(b12)Nemz}/Igh^{tm1.1(b12)Nemz}; Igk^{tm1.1(b12)Nemz}/Igk^{tm1.1(b12)Nemz}
• Genetic Background: involves: C57BL/6N * C57BL/6NTac * FVB/N

immune system

immune system phenotype ( J:205766 )

N • B cells exhibit normal development, recognize HIV antigens, trigger normally and produce high levels of b12 IgG in serum

decreased immature B cell number ( J:205766 )

• in the bone marrow

increased B cell number ( J:205766 )

• in the lymph node

decreased IgM level ( J:205766 )

• slightly

hematopoietic system

decreased immature B cell number ( J:205766 )

• in the bone marrow

increased B cell number ( J:205766 )

• in the lymph node

decreased IgM level ( J:205766 )

• slightly