Phenotypes associated with this allele

• Allele Symbol: Mad2l2^tm1Ymu
• Allele Name: targeted mutation 1, Yoshiki Murakumo
• Allele ID: MGI:5505390
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mad2l2^tm1Ymu/Mad2l2^tm1Ymu	involves: 129 * C57BL/6J	MGI:5505394

Genotype
MGI:5505394

hm1

• Allelic Composition: Mad2l2^tm1Ymu/Mad2l2^tm1Ymu
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation and small testis in Mad2l2^tm1Ymu/Mad2l2^tm1Ymu mice

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:198275 )

• some mice die between E13.5 and after birth

reproductive system

decreased primordial germ cell number ( J:198275 )

• progressive

absent primordial germ cells ( J:198275 )

• at E13.5 in the genital ridge

increased primordial germ cell apoptosis ( J:198275 )

• increased PGC apoptosis during migration

• however, primordial germ cell development and migration are normal

abnormal oogenesis ( J:198275 )

♀ • impaired

absent ovarian follicles ( J:198275 )

♀

small ovary ( J:198275 )

♀

ovary atrophy ( J:198275 )

♀

seminiferous tubule degeneration ( J:198275 )

♂ • atrophic at P14 and P56

small testis ( J:198275 )

♂

decreased testis weight ( J:198275 )

♂ • at P14 and P56

abnormal spermatogenesis ( J:198275 )

♂ • impaired

azoospermia ( J:198275 )

♂

female infertility ( J:198275 )

♀

male infertility ( J:198275 )

♂

growth/size/body

decreased embryo size ( J:198275 )

• at E10.5

decreased birth body size ( J:198275 )

decreased body size ( J:198275 )

• at P28

decreased body weight ( J:198275 )

♂ • at P28, P42, P56 and P70

nervous system

nervous system phenotype ( J:198275 )

N • neuroblast proliferation in the forebrain is normal at E11.5

increased forebrain apoptosis ( J:198275 )

• increased number of apoptotic cells among forebrain neuroblasts at E11.5

behavior/neurological

weakness ( J:198275 )

• feeble at birth

cellular

azoospermia ( J:198275 )

♂

decreased primordial germ cell number ( J:198275 )

• progressive

absent primordial germ cells ( J:198275 )

• at E13.5 in the genital ridge

increased primordial germ cell apoptosis ( J:198275 )

• increased PGC apoptosis during migration

• however, primordial germ cell development and migration are normal

increased forebrain apoptosis ( J:198275 )

• increased number of apoptotic cells among forebrain neuroblasts at E11.5

abnormal oogenesis ( J:198275 )

♀ • impaired

abnormal double-strand DNA break repair ( J:198275 )

• accumulation of double strand breaks in E9.5 embryos and somatic cells around the genital ridge at E13.5

embryo

decreased embryo size ( J:198275 )

• at E10.5

endocrine/exocrine glands

absent ovarian follicles ( J:198275 )

♀

small ovary ( J:198275 )

♀

ovary atrophy ( J:198275 )

♀

seminiferous tubule degeneration ( J:198275 )

♂ • atrophic at P14 and P56

small testis ( J:198275 )

♂

decreased testis weight ( J:198275 )

♂ • at P14 and P56

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:198275 )

• accumulation of double strand breaks in E9.5 embryos and somatic cells around the genital ridge at E13.5