mortality/aging
• fewer than expected mice survive to birth
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Allele Symbol Allele Name Allele ID |
Arhgef12tm1Sgkd targeted mutation 1, Silvio Gutkind MGI:5505411 |
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Summary |
4 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected mice survive to birth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Arhgef11tm1Sgkd/Arhgef11tm1Sgkd Arhgef12tm1Sgkd/Arhgef12tm1Sgkd embryos are less developed with partial branching failure of the cranial vessels
• mice die mid-gestation
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N |
• mice exhibit normal placental trophoblast layer proliferation and differentiation
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• fewer vessels at E9.5 that is more prominent at E10.5
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• less visible blood vessels in the yolk sac at E10
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• with dilated and not well oriented vessels
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• smaller and less developed at E10
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• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
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• fewer vessels at E9.5 that is more prominent at E10.5
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• abnormal blood vessel distribution
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
• however, vessel branching in the trunk
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• less visible blood vessels in the yolk sac at E10
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• with dilated and not well oriented vessels
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• mouse embryonic fibroblasts fail to exhibit increased proliferation in response to thrombin unlike control cells
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• in mouse embryonic fibroblast
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• smaller and less developed at E10
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• fewer embryonic primitive erythrocytes
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• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• fewer than expected mice are produced
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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