All Phenotypes Igf2r<tm1.1(IGF2R)Arte> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^{tm1.1(IGF2R)Arte}	involves: C57BL/6J * C57BL/6NTac	MGI:5505552
ht2	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺	involves: C57BL/6J * C57BL/6NTac	MGI:5505549
ht3	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^tm2Wag	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac	MGI:5505551
cx4	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺	involves: C57BL/6J * C57BL/6NTac	MGI:5505550

Allelic Composition	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^{tm1.1(IGF2R)Arte}
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

growth/size/body

growth/size/body region phenotype ( J:197171 )

N	• rescue of postnatal overgrowth observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Increased body size in Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺ mice when the allele is inherited maternally

mortality/aging

preweaning lethality, incomplete penetrance ( J:197171 )

• when the allele is inherited maternally, fewer than expected pups survive to P10

• however, all pups are viable when this allele is inherited paternally

reproductive system

abnormal uterine horn morphology ( J:197171 )

• dilated, enlarged and fluid filled when the allele is inherited maternally

dilated uterine horn ( J:197171 )

• when the allele is inherited maternally

enlarged uterine horn ( J:197171 )

• when the allele is inherited maternally

decreased litter size ( J:197171 )

• when the allele is inherited maternally

• however, all pups are viable when this allele is inherited paternally

cardiovascular system

increased heart weight ( J:197171 )

• at E14.5 and at E18.5 without hypertrophy when the allele is inherited maternally

• however, heart weight was not disproportional at E18.5

increased heart ventricle size ( J:197171 )

• increased ventricular muscle with blood filled spaces at E18.5 when the allele is inherited maternally

dilated heart ( J:197171 )

• when the allele is inherited maternally

heart hemorrhage ( J:197171 )

• increased ventricular muscle with blood filled spaces at E18.5 when the allele is inherited maternally

growth/size/body

increased heart weight ( J:197171 )

• at E14.5 and at E18.5 without hypertrophy when the allele is inherited maternally

• however, heart weight was not disproportional at E18.5

increased body size ( J:197171 )

• when the allele is inherited maternally

increased body weight ( J:197171 )

• when the allele is inherited maternally

• however, adult weight is normal when the allele is inherited paternally

increased fetal weight ( J:197171 )

• at E14.5, E17.5 and E18.5 when the allele is inherited maternally

embryo

increased placenta weight ( J:197171 )

• at E14.5 and E18.5 when the allele is inherited maternally

Allelic Composition	Igf2r^{tm1.1(IGF2R)Arte}/Igf2r^tm2Wag
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (99 available)
Igf2r^tm2Wag mutation (1 available); any Igf2r mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

Allelic Composition	Igf2^tm1Rob/Igf2^tm1Rob Igf2r^{tm1.1(IGF2R)Arte}/Igf2r⁺
Genetic Background	involves: C57BL/6J * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf2r^{tm1.1(IGF2R)Arte} mutation (0 available); any Igf2r mutation (99 available)
Igf2^tm1Rob mutation (1 available); any Igf2 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197171 )

N	• rescue of preweaning lethality observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

growth/size/body

growth/size/body region phenotype ( J:197171 )

N	• rescue of postnatal overgrowth observed when Igf2r^{tm1.1(IGF2R)Arte} is inherited maternally

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