Phenotypes associated with this allele

• Allele Symbol: Tle3^tm1.1Pton
• Allele Name: targeted mutation 1.1, Peter Tontonoz
• Allele ID: MGI:5505553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tle3^tm1.1Pton/Tle3^tm1.1Pton Tg(Adipoq-cre)1Evdr/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ	MGI:5505584

Genotype
MGI:5505584

cn1

• Allelic Composition: Tle3^tm1.1Pton/Tle3^tm1.1Pton; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:198134 )

• browner in color than in control mice

abnormal brown fat cell morphology ( J:198134 )

• increase in cells with multilocular lipid droplets characteristic of young brown adipose tissue

abnormal inguinal fat pad morphology ( J:198134 )

• evidence of browning with increased numbers of cells with multilocular lipid droplets

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:198134 )

• improved ability to respond to cold exposure

increased core body temperature ( J:198134 )

• in respond to cold exposure

increased energy expenditure ( J:198134 )

• when housed in metabolic cages

behavior/neurological

behavior/neurological phenotype ( J:198134 )

N • mice exhibit normal activity level and food intake