Phenotypes associated with this allele

• Allele Symbol: Ephb2^tm1.1Meg
• Allele Name: targeted mutation 1.1, Michael E Greenberg
• Allele ID: MGI:5505687
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ephb1^tm1.1Meg/Ephb1^tm1.1Meg Ephb2^tm1.1Meg/Ephb2^tm1.1Meg Ephb3^tm1.1Meg/Ephb3^tm1.1Meg	involves: 129S4/SvJae * C57BL/6	MGI:5505691

Genotype
MGI:5505691

cx1

• Allelic Composition: Ephb1^tm1.1Meg/Ephb1^tm1.1Meg; Ephb2^tm1.1Meg/Ephb2^tm1.1Meg; Ephb3^tm1.1Meg/Ephb3^tm1.1Meg
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:197489 )

N • in the absence of PP1, brain morphology is normal

N • 1-NA-PP1-treated mice exhibit normal synaptogenesis or formation and maintenance of functional synapse

abnormal axon extension ( J:197489 )

• ventrotemporal retina explants treated with ephrin-B2 and 1-NA-PP1 exhibit collapse of growth cones unlike control explants

• ventrotemporal retina explants treated with ephrin-B and 3-MB-PP1 exhibit collapse of growth cones unlike control explants

• after 1-NA-PP1 treatment from E13.5 to E16.5, ipsilateral retinal projections from retinal ganglion cells is reduced compared to in control mice

decreased corpus callosum size ( J:197489 )

• partial agenesis with a gap in the dorsal midline region in mice treated with 1-NA-PP1

cellular

abnormal axon extension ( J:197489 )

• ventrotemporal retina explants treated with ephrin-B2 and 1-NA-PP1 exhibit collapse of growth cones unlike control explants

• ventrotemporal retina explants treated with ephrin-B and 3-MB-PP1 exhibit collapse of growth cones unlike control explants

• after 1-NA-PP1 treatment from E13.5 to E16.5, ipsilateral retinal projections from retinal ganglion cells is reduced compared to in control mice