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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Mrgpra3-GFP/cre)#Xzd
transgene insertion, Xinzhong Dong
MGI:5506535
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Trpv1tm1Jul/Trpv1tm1Jul
Tg(Mrgpra3-GFP/cre)#Xzd/0
involves: 129P2/OlaHsd * 129X1/SvJ MGI:5506549
cn2
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Tg(Mrgpra3-GFP/cre)#Xzd/0
involves: C57BL/6 MGI:5506548


Genotype
MGI:5506549
cn1
Allelic
Composition
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde/Gt(ROSA)26Sor+
Trpv1tm1Jul/Trpv1tm1Jul
Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Trpv1,ECFP)Mde mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation (0 available)
Trpv1tm1Jul mutation (1 available); any Trpv1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• cheek injection of capsaicin does not evoke pain behavior (forepaw facial wiping), in contrast to robust facial wiping observed in treated wild-type
• mice have impaired nociceptive responses, showing increased latencies in tail-immersion and hot plate paradigms

integument
• robust itch behavior is observed after cheek injection of capsaicin compared to little hindpaw scratching seen in treated wild-type




Genotype
MGI:5506548
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Tg(Mrgpra3-GFP/cre)#Xzd/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Mrgpra3-GFP/cre)#Xzd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• responses to acute noxious heat, cold, mechanical and chemical stimulation after diphtheria toxin (DTX) treatment are similar to control littermates
• normal motor function is observed following DTX treatment
• injection of capsaicin to the cheek induces normal pain-invoked facial wiping behavior in DTX-treated animals comparable to controls
• cheek injection of beta-alanine induces robust scratching response in DTX-treated mice similar to the behavior in treated controls

nervous system

integument
• scratching behavior is reduced relative to controls in DTX-treated mice after injection of alpha-methyl-serotonin or endothelin-1
• in models of dry skin pruritus and allergic chronic itch, DTX-treated mice show reduced scratching behavior compared to controls
• injection of chloroquine into cheeks of DTX-treated mice abolishes the hindpaw cheek-scratching elicited in DTX-treated controls
• hindpaw scratching induced by histamine administration to the cheek is reduced in DTX-treated mice relative to treated controls
• subcutaneous injection of histamine into the napes of DTX-treated mice results in a reduced scratching behavior compared to DTX-treated controls
• site-directed scratching is abolished in DTX-treated mutants following injection of either BAN8-22 or SLIGRL-NH2 (pruritogens that activate Mrgprx1)
• after subcutaneous cloroquine injection into the necks of DTX-treated mice, site-directed scratching is significantly reduced compared to DTX- and cholorquine-treated control littermates





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory