All Phenotypes Scn8a<m10J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn8a^m10J
mutation 10 Jackson
MGI:5506774

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn8a^m10J/Scn8a^m10J	FVB/NJ-Scn8a^m10J/GrsrCx	MGI:5506797
ht2	Scn8a^m10J/Scn8a⁺	FVB/NJ-Scn8a^m10J/GrsrCx	MGI:5882508
cx3	Gars1^C201R/Gars1⁺ Scn8a^m10J/Scn8a⁺	involves: BALB/cAnN * C3H/HeJ * FVB/NJ	MGI:5882425
cx4	Gars1^Nmf249/Gars1⁺ Scn8a^m10J/Scn8a⁺	involves: C57BL/6J * FVB/NJ	MGI:5882509

Allelic Composition	Scn8a^m10J/Scn8a^m10J
Genetic Background	FVB/NJ-Scn8a^m10J/GrsrCx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^m10J mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

tremors ( J:199990 )

• generally found by 2 weeks of age

ataxia ( J:199990 )

• beginning after 2 weeks of age and progressing to paralysis

paralysis ( J:199990 )

• although no demyelination was evident in nerve cross-sections and conduction velocities were normal at 16 days of age, homozygotes display tremors, ataxia, and progressive paralysis until death by 21 to 24 days of age

growth/size/body

decreased body size ( J:199990 )

• generally evident by 2 weeks of age

mortality/aging

postnatal lethality, complete penetrance ( J:199990 )

• homozygotes die between 21 and 24 days of age

Allelic Composition	Scn8a^m10J/Scn8a⁺
Genetic Background	FVB/NJ-Scn8a^m10J/GrsrCx

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a^m10J mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased nerve conduction velocity ( J:240096 )

• heterozgyotes have a modest reduction in nerve conduction velocity

Allelic Composition	Gars1^C201R/Gars1⁺ Scn8a^m10J/Scn8a⁺
Genetic Background	involves: BALB/cAnN * C3H/HeJ * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^C201R mutation (2 available); any Gars1 mutation (42 available)
Scn8a^m10J mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:240096 )

• neuromuscular junction innervation is decreased compared with either parental mutants, with an increase in both partial innervation and denervation

abnormal neuromuscular synapse morphology ( J:240096 )

decreased nerve conduction velocity ( J:240096 )

• nerve conduction velocity is lower than in either parental mutant

Allelic Composition	Gars1^Nmf249/Gars1⁺ Scn8a^m10J/Scn8a⁺
Genetic Background	involves: C57BL/6J * FVB/NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gars1^Nmf249 mutation (1 available); any Gars1 mutation (42 available)
Scn8a^m10J mutation (0 available); any Scn8a mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

skeletal muscle atrophy ( J:240096 )

• slightly more severe than the parental heterozygote

nervous system

abnormal neuromuscular synapse morphology ( J:240096 )

• decreased neuromuscular junction innervation compared with either parental heterozygotes

decreased nerve conduction velocity ( J:240096 )

• decreased relative to either parental heterozygote

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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