Phenotypes associated with this allele

• Allele Symbol: Kdm6a^{tm1b(EUCOMM)Jae}
• Allele Name: targeted mutation 1b, Rudolf Jaenisch
• Allele ID: MGI:5507843
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm6a^tm1b(EUCOMM)Jae/Kdm6a^tm1b(EUCOMM)Jae	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5507863
ot2	Kdm6a^tm1b(EUCOMM)Jae/Y	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:5507864

Genotype
MGI:5507863

hm1

• Allelic Composition: Kdm6a^{tm1b(EUCOMM)Jae}/Kdm6a^{tm1b(EUCOMM)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:188485 )

♀ • no live homozygotes are born

♀ • only abnormal or partially resorbed females at E11,5

♀ • high frequency of resorptions at E12.5 and E13.5

♀ • no live female embryos after E12.5

cardiovascular system

abnormal heart development ( J:188485 )

♀ • heart malformations in abnormal embryos at E10.5

nervous system

abnormal neural tube closure ( J:188485 )

♀ • neural tube closure defects

embryo

abnormal developmental patterning ( J:188485 )

♀ • delayed development observed at E9.5

failure of initiation of embryo turning ( J:188485 )

♀ • observed at E9.5

abnormal neural tube closure ( J:188485 )

♀ • neural tube closure defects

delayed somite formation ( J:188485 )

♀ • reduced number of somites seen at E9.5

increased trophoblast giant cell number ( J:188485 )

♀ • large number of giasnt trophoblasts are seen in teratomas derived from homozygous female knockout ES cells

Genotype
MGI:5507864

ot2

• Allelic Composition: Kdm6a^{tm1b(EUCOMM)Jae}/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:188485 )

♂ • hemizygotes are underrepresented

♂ • some abnormal embryos at E11.5

♂ • apparently normal males at E13.5 but in reduced numbers

growth/size/body

decreased birth weight ( J:188485 )

♂ • surviving mice are smaller at birth but viable

postnatal growth retardation ( J:188485 )

♂ • surviving mice remain small throughout adulthood but are viable

reproductive system

reproductive system phenotype ( J:188485 )

♂N • spermatogenesis is normal although male knockout ES cells fail to go germline